5'-Deoxy-5'-methylthioadenosine (Methylthioadenosine), Adenosine A1 receptor agonist (ab141257)
Key features and details
- Potent adenosine A1 receptor agonist
- CAS Number: 2457-80-9
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
5'-Deoxy-5'-methylthioadenosine (Methylthioadenosine), Adenosine A1 receptor agonist -
Description
Potent adenosine A1 receptor agonist -
Alternative names
- 5'-Deoxy-5'-(methylthio)adenosine
- 5'-DEOXY-5'-METHYLTHIOADENOSINE
- 5'-methylthioadenosine
see all -
Biological description
Potent A1 receptor agonist (Ki = 10 μM). Also an A2 receptor antagonist and potent cAMP phosphodiesterase inhibitor (Ki = 62 μM). Regulates gene expression, proliferation, differentiation and apoptosis. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.
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Purity
> 98% -
CAS Number
2457-80-9 -
Chemical structure
Properties
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Chemical name
(2R,3R,4S,5S)-2-(6-Aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol -
Molecular weight
297.33 -
Molecular formula
C11H15N5O3S -
PubChem identifier
439176 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CSCC1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)O -
Source
Synthetic
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Research areas
