Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant human IL-10RA protein (Fc Chimera) (ab214604)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: >= 98% SDS-PAGE
  • Endotoxin level:
  • Active: Yes
  • Suitable for: Functional Studies, SDS-PAGE

Description

  • Product name

    Recombinant human IL-10RA protein (Fc Chimera)
    See all IL-10RA proteins and peptides

  • Biological activity

    Measured by its ability to inhibit IL-10-dependent proliferation of MC/9- 2 mouse mast cells.

  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    HEK 293 cells

  • Accession

    Q13651

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      HGTELPSPP SVWFEAEFFH HILHWTPIPN QSESTCYEVA LLRYGIESWN SISNCSQTLS YDLTAVTLDL YHSNGYRARV RAVDGSRHSN WTVTNTRFSV DEVTLTVGSV NLEIHNGFIL GKIQLPRPKM APANDTYESI FSHFREYEIA IRKVPGNFTF THKKVKHENF SLLTSGEVGE FCVQVKPSVA SRSNKGMWSK EECISLTRQY FTVTN

    • Predicted molecular weight

      24 kDa

    • Amino acids

      22 to 235

    • Additional sequence information

      Extracellular domain fused to the N-terminus of the Fc region of human IgG1 (AAH28082.1).

    • Specifications

    Our Abpromise guarantee covers the use of ab214604 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Functional Studies

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

      Constituent: 100% PBS

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • Reconstitution
      Reconstitute vial with 50 µl sterile water to a concentration of 1mg/ml. Add 1X PBS to the desired protein concentration.

    General Info

    • Alternative names

      • CD210
      • CDw210a
      • CDw210a antigen
      • HIL 10R
      • HIL10R
      • I10R1_HUMAN
      • IL 10R
      • IL 10R 1
      • IL 10R A
      • IL 10R1
      • IL-10 receptor subunit alpha
      • IL-10R subunit 1
      • IL-10R subunit alpha
      • IL-10R1
      • IL-10RA
      • IL10R
      • IL10R1
      • IL10RA
      • Interleukin 10 receptor alpha
      • Interleukin 10 receptor alpha chain
      • Interleukin-10 receptor subunit 1
      • Interleukin-10 receptor subunit alpha
      see all

    • Function

      Receptor for IL10; binds IL10 with a high affinity.

    • Tissue specificity

      Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.

    • Involvement in disease

      Inflammatory bowel disease 28

    • Sequence similarities

      Belongs to the type II cytokine receptor family.

    • Cellular localization

      Membrane.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab214604? Please let us know so that we can cite the reference in this datasheet.

ab214604 has not yet been referenced specifically in any publications.

Preparation and Storage

  • CD210
  • CDw210a
  • CDw210a antigen

Images

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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