5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor (ab120842)
Key features and details
- Potent DNMT1 inhibitor. Induces DNA hypomethylation.
- CAS Number: 2353-33-5
- Purity: > 99%
- Soluble in water to 50 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor -
Description
Potent DNMT1 inhibitor. Induces DNA hypomethylation. -
Alternative names
- 5-AzadCyD
- Dacogen
- Decitabine
- NSC 127716
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Biological description
Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC50 = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro. Active in vivo.
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Purity
> 99% -
CAS Number
2353-33-5 -
Chemical structure
Properties
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Chemical name
4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one -
Molecular weight
228.21 -
Molecular formula
C8H12N4O4 -
PubChem identifier
451668 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM and in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O -
Source
Synthetic
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Research areas
