4-DAMP, Muscarinic receptor antagonist (ab120144)
Key features and details
- Muscarinic receptor antagonist
- CAS Number: 1952-15-4
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
4-DAMP, Muscarinic receptor antagonist -
Description
Muscarinic receptor antagonist -
Biological description
Muscarinic antagonist. (Ki values for human receptors are 0.57 (M1), 7.3 (M2), 0.37 (M3), 0.72 (M4) and 0.55 nM (M5)).
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Purity
> 98% -
CAS Number
1952-15-4 -
Chemical structure
Properties
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Chemical name
4-Diphenylacetoxy-N-methylpiperidine methiodide -
Molecular weight
451.35 -
Molecular formula
C21H26INO2 -
PubChem identifier
3014059 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[I-].O=C(OC1CC[N+](C)(C)CC1)C(c2ccccc2)c3ccccc3 -
Source
Synthetic
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Research areas
Images
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Cellular activation - 4-DAMP, Muscarinic receptor antagonist (ab120144) Image from Lee BH, et al. Plos One, 8(1), e53113. Fig 2,; doi: 10.1371/journal.pone.0053113
(A) rhAQP5 vector-transfected HSG cells were stimulated with CCh (100 µM) in the presence or absence of 4-DAMP (10 µM), prenzepine (10 µM), and mixture of 4-DAMP and prenzepine (M3R or M1R specific antagonist, respectively).
(B) To monitor hAQP5 trafficking, original GFP pictures in (A) were converted into 'Fire' 3D LUT (lookup tables) setting in ImageJ software and only GFP signal above the fluorescent signal threshold (?80, red or yellow color in converted picture), was captured in (B) as positive GFP signal. Yellow arrows indicate the positive GFP signal on the membrane and green arrows indicates signal in the cytoplasm in HSG cells.