Z-FA-FMK, Cathepsin B inhibitor (ab141384)
Key features and details
- Cathepsin B inhibitor. Negative control for caspase inhibitors.
- CAS Number: 197855-65-5
- Purity: > 95%
- Supplied in DMSO (10 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
Z-FA-FMK, Cathepsin B inhibitor -
Description
Cathepsin B inhibitor. Negative control for caspase inhibitors. -
Biological description
Irreversible cysteine protease inhibitor. Cell-permeable caspase effector inhibitor. Selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Inhibits cathepsin B, L, and S, papain and cruzain. Induces apoptosis and necrosis. Shows anti-inflammatory effects in vivo. Negative control for caspase inhibitors. Solid form also available (ab141484).
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Purity
> 95% -
CAS Number
197855-65-5 -
Chemical structure
Properties
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Molecular weight
386.42 -
Molecular formula
C21H23FN2O4 -
Sequence
FA (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK) -
PubChem identifier
122019 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Supplied in DMSO (10 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C(=O)CF)NC(=O)C(CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2 -
Source
Synthetic
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Research areas
