Z-AEVD-FMK, caspase-10 and related caspases inhibitor (ab142028)
Key features and details
- Irreversible inhibitor of caspase-10 and related caspases
- CAS Number:
- Purity: > 95%
- Supplied in DMSO (10 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
Z-AEVD-FMK, caspase-10 and related caspases inhibitor -
Description
Irreversible inhibitor of caspase-10 and related caspases -
Biological description
Irreversible inhibitor of caspase-10 (Ki = 320 nM) and related caspases. Inhibits FasL- and pyrimethamine-induced apoptosis. Cell-permeable. Active in vivo. -
Purity
> 95% -
Chemical structure
Properties
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Molecular weight
610.63 -
Molecular formula
C28H39FN4O10 -
Sequence
AEVD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Glu-2 = Glu(OMe); Asp-4 = Asp(OMe)) -
PubChem identifier
44135225 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Supplied in DMSO (10 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(C)NC(=O)OCC1=CC=CC=C1 -
Source
Synthetic
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Research areas
