WZ 4003, NUAK kinase inhibitor (ab144820)
Key features and details
- Potent, selective NUAK kinase inhibitor
- CAS Number: 1214265-58-3
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
WZ 4003, NUAK kinase inhibitor -
Description
Potent, selective NUAK kinase inhibitor -
Biological description
Potent, selective NUAK kinase inhibitor (IC50 values are 20 and 100 nM for NUAK1 and NUAK2, respectively). Impairs invasive potential of U2OS cells. Shows antiproliferative effects.
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Purity
> 98% -
CAS Number
1214265-58-3 -
Chemical structure
Properties
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Chemical name
N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide -
Molecular weight
497.00 -
Molecular formula
C25H29ClN6O3 -
PubChem identifier
72200024 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCN(CC1)c4cc(OC)c(Nc3nc(Oc2cccc(NC(=O)CC)c2)c(Cl)cn3)cc4 -
Source
Synthetic
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Research areas
