WYE 687 dihydrochloride, mTOR inhibitor (ab254329)
Key features and details
- ATP-competitive, selective and highly potent mTOR inhibitor
- CAS Number: 1062161-90-3
- Purity: > 98%
Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
WYE 687 dihydrochloride, mTOR inhibitor -
Description
ATP-competitive, selective and highly potent mTOR inhibitor -
Alternative names
- WYE 687 dihydrochloride
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Biological description
ATP-competitive, selective and highly potent mTOR inhibitor (IC50 = 7nM). Displays selectivity over PI 3-Kα and PI 2-Kγ by 100-fold and 500-fold respectively. Inhibits mTORC1 and mTORC2 substrate (s6K, SGK and Akt) phosphorylation, blocks VEGF secretion and HIF-1α expression. Effect of G1 cycle arrest and selective apoptosis has anti-proliferative effect in cancer cells.
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Purity
> 98% -
General notes
Protect from air and light.
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CAS Number
1062161-90-3 -
Chemical structure
Properties
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Chemical name
Methyl N-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamate
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Molecular weight
528.61 -
Molecular formula
C28H32N8O3 -
PubChem identifier
25229450 -
Storage instructions
Shipped at 4°C. Store at -20°C long term. Store In the Dark. -
Solubility overview
Soluble in DMSO
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)CC5=CN=CC=C5)C(=N2)N6CCOCC6 -
Source
Synthetic
