WP1066, JAK/STAT3 inhibitor (ab141440)
Key features and details
- JAK/STAT3 inhibitor; AG 490 analog
- CAS Number: 857064-38-1
- Purity: > 97%
- Soluble in DMSO to 25 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
WP1066, JAK/STAT3 inhibitor -
Description
JAK/STAT3 inhibitor; AG 490 analog -
Biological description
JAK/STAT3 inhibitor (IC50 = 2.3 μM). More potent analog of AG 490 (ab120950). Antitumor activity in vitro and in vivo. Cell-permeable. Blood-brain barrier permeable. -
Purity
> 97% -
CAS Number
857064-38-1 -
Chemical structure
Properties
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Chemical name
(E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide -
Molecular weight
356.22 -
Molecular formula
C17H14BrN3O -
PubChem identifier
11210478 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N -
Source
Synthetic
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Research areas