WAY-100635 maleate, 5-HT1A receptor antagonist (ab120550)
Key features and details
- Potent, selective, silent 5-HT1A receptor antagonist
- CAS Number: 634908-75-1
- Purity: > 98%
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
WAY-100635 maleate, 5-HT1A receptor antagonist -
Description
Potent, selective, silent 5-HT1A receptor antagonist -
Biological description
Potent, selective, silent 5-HT1A receptor antagonist (IC50 = 1.35 nM).
Displays >100-fold selectivity for 5-HT1Arelative to a range of other CNS receptors including other 5-HT subtypes, adrenoceptors, dopamine, GABA, histamine and ion channels. Binds selectively to rodent brain 5-HT1A receptors in vivo (iv admin). Unlike WAY100135, WAY100635 displays no partial agonist activity in the ventral hippocampus of rats. -
Purity
> 98% -
CAS Number
634908-75-1 -
Chemical structure
Properties
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Chemical name
N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate salt -
Molecular weight
538.64 -
Molecular formula
C25H34N4O2.C4H4O4 -
PubChem identifier
11957721 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.C(=C\C(=O)O)\C(=O)O -
Source
Synthetic
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Research areas
