LY 341495 disodium salt, group II/group III mGlu antagonist (ab120818)
Key features and details
- Water-soluble group II/group III mGlu antagonist. Disodium salt of LY 341495 (ab120199).
- CAS Number: 201943-63-7
- Purity: > 98%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
LY 341495 disodium salt, group II/group III mGlu antagonist -
Description
Water-soluble group II/group III mGlu antagonist. Disodium salt of LY 341495 (ab120199). -
Biological description
Water-soluble and very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Disodium salt of LY 341495 (ab120199) which displays Kd values of 1.67 (human mGlu2), 0.75 (mGlu3), 31.6 (mGlu6), 72.7 (mGlu7a) and 14 (human mGlu8a receptors) nM. LY 341495 displays IC50 values of 7.8, 8.2 and 22 μM for mGlu1a, mGlu5a and mGlu4 receptors, respectively. It is readily brain penetrant and active in vivo.
Also available in simple stock solutions (ab144500) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity
> 98% -
CAS Number
201943-63-7 -
Chemical structure
Properties
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Chemical name
(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl)propanoic acid disodium salt -
Molecular weight
397.34 -
Molecular formula
C20H17NNa2O5 -
PubChem identifier
9819927 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1[C@@H]([C@H]1[C@@](CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O -
Source
Synthetic
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Research areas
