VX-680 (MK-0457), Aurora kinase inhibitor (ab120799)
Key features and details
- Aurora kinase inhibitor
- CAS Number: 639089-54-6
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
VX-680 (MK-0457), Aurora kinase inhibitor -
Description
Aurora kinase inhibitor -
Alternative names
- MK0457
- Tozasertib
- VX680
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Biological description
Aurora kinase inhibitor (Ki values are 0.6, 18 and 4.6 nM for Aurora kinase A, B and C, respectively). Exhibits selectivity for Aurora kinase over 190 other protein kinases. Blocks cell-cycle progression and induces apoptosis in a diverse range of human tumor cell lines in vitro. Inhibits tumor growth in a variety of in vivo xenograft models.
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Purity
> 98% -
CAS Number
639089-54-6 -
Chemical structure
Properties
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Chemical name
N-[4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-
3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide -
Molecular weight
464.59 -
Molecular formula
C23H28N8OS -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCN(CC1)c4cc(nc(Sc3ccc(NC(=O)C2CC2)cc3)n4)Nc5cc(C)nn5 -
Source
Synthetic