VU0155041, positive allosteric mGluR4 agonist (ab120244)
Key features and details
- PAM for mGluR4
- CAS Number:
- Purity: > 99%
- Soluble in 1 eq. NaOH to 100 mM, in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
VU0155041, positive allosteric mGluR4 agonist -
Description
PAM for mGluR4 -
Biological description
Positive allosteric selective modulator at mGluR4 (EC50 values are 798 and 693 nM at human and rat mGluR4 receptors, respectively). It has advantages over PHCCC (ab120043) as it is more potent. Shows limited blood-brain barrier permeability. Active in behavioural models of Parkinson's disease following icv injection. Available in water-soluble form - please see VU0155041 sodium salt (ab120248).
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Purity
> 99% -
Chemical structure
Properties
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Chemical name
cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid -
Molecular weight
316.18 -
Molecular formula
C14H15Cl2NO3 -
PubChem identifier
2933724 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 1 eq. NaOH to 100 mM, in DMSO to 100 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
OC(=O)C2CCCCC2C(=O)Nc1cc(Cl)cc(Cl)c1 -
Source
Synthetic
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Research areas
