GYKI 53655 hydrochloride, Non-competitive AMPA / kainate receptor antagonist (ab120490)
Key features and details
- Non-competitive AMPA / kainate receptor antagonist
- CAS Number: 143692-48-2
- Purity: > 99%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GYKI 53655 hydrochloride, Non-competitive AMPA / kainate receptor antagonist -
Description
Non-competitive AMPA / kainate receptor antagonist -
Alternative names
- GYKI53655
- LY300168
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Biological description
Non-competitive AMPA and kainate receptor antagonist. (IC50 values for inhibition of AMPA-mediated responses in cells expressing human GluR1 and GluR4 are 6 and 5 µM, respectively). Analog of GYKI 52466 (ab120336). Anticonvulsant in vivo. At higher concentrations blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM).
Also available in simple stock solutions (ab144499) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity
> 99% -
CAS Number
143692-48-2 -
Chemical structure
Properties
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Chemical name
1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride -
Molecular weight
388.85 -
Molecular formula
C19H20N4O3.HCl -
PubChem identifier
126757 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Nc1ccc(cc1)C3=NN(C(C)Cc2cc4OCOc4cc23)C(=O)NC -
Source
Synthetic
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Research areas
