Valinomycin from Streptomyces fulvissimus, K+ selective ionophore (ab120852)
Key features and details
- K+ selective ionophore
- CAS Number: 2001-95-8
- Soluble in DMSO to 25 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Streptomyces fulvissimus
Overview
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Product name
Valinomycin from Streptomyces fulvissimus, K+ selective ionophore -
Description
K+ selective ionophore -
Biological description
K+ selective ionophore. Natural dodecadepsipeptide. Antitumor, antifungal and antibacterial effects. Apoptosis due to caspase independent mechanisms.
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CAS Number
2001-95-8 -
Chemical structure
Properties
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Chemical name
Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl) -
Molecular weight
1111.33 -
Molecular formula
C54H90N6O18 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Streptomyces fulvissimus
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Research areas
Images
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Functional Studies - Valinomycin from Streptomyces fulvissimus, K+ selective ionophore (ab120852)ab56889 staining mitodusin2 in MEF1 cells treated with valinomycin from Streptomyces fulvissimus (ab120852), by ICC/IF. Decrease in mitofusin2 expression with increased concentration of withaferin valinomycin from Streptomyces fulvissimus, as described in literature.
The cells were incubated at 37°C for 3h in media containing different concentrations of ab120852 (valinomycin from Streptomyces fulvissimus) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab56889 (10 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
