Herbimycin A, Src tyrosine kinase inhibitor (ab142310)
Key features and details
- Cell-permeable Src tyrosine kinase inhibitor
- CAS Number: 70563-58-5
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Streptomyces hygroscopicus
Overview
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Product name
Herbimycin A, Src tyrosine kinase inhibitor -
Description
Cell-permeable Src tyrosine kinase inhibitor -
Biological description
Cell-permeable Src tyrosine kinase inhibitor and ansamycin antibiotic. Binds to the SH domain and inhibits p60v-src and p210BCR-ABL activity. Specific IKKβ and angiogenesis inhibitor. Anti-bacterial, anti-inflammatory and antitumor effects. Active in vitro and in vivo. -
Purity
> 98% -
CAS Number
70563-58-5 -
Chemical structure
Properties
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Chemical name
[(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl]carbamate -
Molecular weight
574.66 -
Molecular formula
C30H42N2O9 -
PubChem identifier
6436247 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C=C(C1OC)C2=O)C)OC)OC(=O)N)C)C)OC)OC -
Source
Streptomyces hygroscopicus
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Research areas