UC2288, p21 inhibitor (ab146969)
Key features and details
- Novel, selective, cell permeable p21 inhibitor
- CAS Number: 1394011-91-6
- Purity: > 98%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
UC2288, p21 inhibitor -
Description
Novel, selective, cell permeable p21 inhibitor -
Alternative names
- p21/Cip1/CKI/Waf1 Inhibitor
- t-CTTU
- trans-1-(4-Chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea
- UC-2288
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Biological description
Cell-permeable, phenylcyclohexyl-urea based compound that selectively downregulates the expression of p21, independent of p53 expression, at either transcription or post-transcriptional level. Attenuates p21 protein levels with minimal effect on p21 protein stability. Has no significant effect on the activities of Raf kinases, VEGFR2 kinase, or the phosphorylation state of ERK. Effectively inhibits the growth of multiple cancer cell lines (GI50 = ~ 10 µM against NCI60 cell lines).
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Purity
> 98% -
CAS Number
1394011-91-6 -
Chemical structure
Properties
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Chemical name
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((1r,4r)-4-(5-(trifluoromethyl)pyridin-2-yloxy)cyclohexyl)urea -
Molecular weight
481.82 -
Molecular formula
C20H18ClF6N3O2 -
PubChem identifier
60196635 -
Storage instructions
Shipped at Room Temperature. Store at +4°C. Store In the Dark. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CC(CCC1NC(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F)OC3=NC=C(C=C3)C(F)(F)F -
Source
Synthetic