Tubastatin A hydrochloride, HDAC6 inhibitor (ab141415)
Key features and details
- Potent, selective HDAC6 inhibitor
- CAS Number: 1239262-52-2
- Purity: > 98%
- Soluble in DMSO to 100 mM and in water to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Tubastatin A hydrochloride, HDAC6 inhibitor -
Description
Potent, selective HDAC6 inhibitor -
Biological description
Potent, selective HDAC6 inhibitor (IC50 values are 4 and 900 nM for HDAC6 and HDAC8 respectively). Inhibits LPS-induced cytokine production in macrophages (IC50 values are 272 and 712 nM for TNF-α and IL-6 respectively). Induces α-tubulin hyperacetylation. Shows anti-inflammatory and peripheral neuroprotective effects in vivo. -
Purity
> 98% -
CAS Number
1239262-52-2 -
Chemical structure
Properties
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Chemical name
N-Hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride -
Molecular weight
371.86 -
Molecular formula
C20H21N3O2.HCl -
PubChem identifier
57336514 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in water to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO.Cl -
Source
Synthetic
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Research areas
