Tryptanthrin, immunomodulator (ab269884)
Key features and details
- Indoloquinazoline alkaloid with broad pharmacological activity
- CAS Number: 13220-57-0
- Soluble in DMSO to 100 mM
- Form / State: Solid
Overview
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Product name
Tryptanthrin, immunomodulator -
Description
Indoloquinazoline alkaloid with broad pharmacological activity -
Biological description
Indoloquinazoline alkaloid with broad pharmacological activity. Immunomodulatory activity. Blocks BV2 microglia activation in response to LPS. Inhibits pro-inflammatory cytockine production via Nrf2, HO-1 and NFκB pathways. Inhibits indoleamine 2,3-dioxygenase 2 (IC50 = 5-17 μM). Promotes neuronal differentiation of human neuroblastoma cells. Also reported to have anti-cancer, anti-microbial and anti-oxidant activity.
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CAS Number
13220-57-0 -
Chemical structure
Properties
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Chemical name
Indolo[2,1-b]quinazoline-6,12-dione -
Molecular weight
248.24 -
Molecular formula
C15H8N2O2 -
PubChem identifier
73549 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Toxic, refer to SDS for further information.
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SMILES
C1=CC=C2C(=C1)C(=O)N3C4=CC=CC=C4C(=O)C3=N2
Images
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Chemical Structure - Tryptanthrin, immunomodulator (ab269884)
Chemical structure of Tryptanthrin, immunomodulator, 13220-57-0
