Tripolin A, Aurora A and B inhibitor (ab144377)
Key features and details
- Non-ATP competitive Aurora A and B inhibitor. Mitotic spindle microtubule regulator.
- CAS Number: 1148118-92-6
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Tripolin A, Aurora A and B inhibitor -
Description
Non-ATP competitive Aurora A and B inhibitor. Mitotic spindle microtubule regulator. -
Biological description
Non-ATP competitive Aurora A and B inhibitor (IC50 values are 1.5 and 7 μM for Aurora A and B respectively). Mitotic spindle microtubule regulator. Tripolin B (ab144378) analog. Reduces localization of pAurora A on spindle microtubules. Inhibits EGFR, FGFR, KDR and IGF1R (IC50 values are 11, 34, 18 and 15 μM respectively). -
Purity
> 98% -
CAS Number
1148118-92-6 -
Chemical structure
Properties
-
Chemical name
(3Z)-3-[(2,5-Dihydroxyphenyl)methylidene]-1H-indol-2-one -
Molecular weight
253.25 -
Molecular formula
C15H11NO3 -
PubChem identifier
14685351 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
C1=CC=C2C(=C1)/C(=C/C3=C(C=CC(=C3)O)O)/C(=O)N2 -
Source
Synthetic
-
Research areas