Potent, selective, ATP-competitive mTOR inhibitor. Inhibits mTORC1 (IC₅₀ = 2.1 nM) in in vitro kinase activity assays. Displays 800-fold selectivity for mTOR over PI3K (cellular EC₅₀ values are 0.25 and 200 nM for mTOR and PI3K respectively). Attenuates phosphorylation of mTOR downstream targets, inhibits cell proliferation of several cancer cell types, and induces apoptosis and autophagy. Also exhibits potent biochemical and cellular activity against phosphatidylinositol-3 kinase-like kinase (PIKK) family kinases including ATM, ATR and DNA-PK (EC₅₀ values are 28 nM, 35 nM and 118 nM respectively). Has significantly improved bioavailability (54%), metabolic stability, and plasma exposure compared to Torin 1 (ab218606).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Refer to SDS for further information.

Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Synthetic

• Cell Biology
• Cell Cycle
• Cell Cycle Inhibitors
• Other

• Epigenetics and Nuclear Signaling
• DNA / RNA
• DNA Damage & Repair
• DNA Damage Response
• DNA Damage Recognition

• Cancer
• Cell cycle
• Cell cycle inhibitors
• Other

• Cardiovascular
• Heart
• Cardiogenesis
• Transcription factors/regulators

• Kits/ Lysates/ Other
• Kits
• ELISA Kits
• ELISA Kits
• Growth factors and hormones ELISA kits

• Metabolism
• Types of disease
• Obesity