Human proANP peptide (ab42236)
Key features and details
- Suitable for: Blocking
-
Product name
Human proANP peptide
See all proANP proteins and peptides -
Accession
-
Animal free
No -
Nature
Synthetic -
-
Species
Human -
Sequence
NPMYNAVSNADLMDFKNLLDHLEEKMPLED -
Amino acids
26 to 55
-
Preparation and Storage
-
Alternative names
- ANF
- ANF_HUMAN
- ANP
see all -
Function
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. -
Involvement in disease
Atrial standstill 2
Atrial fibrillation, familial, 6 -
Sequence similarities
Belongs to the natriuretic peptide family. -
Post-translational
modificationsCleaved by CORIN upon secretion to produce the functional hormone.
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity. -
Cellular localization
Secreted. - Information by UniProt
