Tofacitinib, Janus kinase (JAK) inhibitor (ab142068)
Key features and details
- Potent, cell-permeable Janus kinase (JAK) inhibitor
- CAS Number: 477600-75-2
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Tofacitinib, Janus kinase (JAK) inhibitor -
Description
Potent, cell-permeable Janus kinase (JAK) inhibitor -
Alternative names
- 1-(Cyanoacetyl)-4-methyl-N-methyl-N-1H-pyrrolo[2,3-d]pyrimidin-4-yl-3-piperidinamine
- CP-690550
- Tasocitinib
- Xeljanz
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Biological description
Potent, cell-permeable Janus kinase 3 (JAK3) inhibitor with some JAK1 inhibitory activity as well. Pyrrolo[2,3-d]pyrimidine derivative. Blocks downstream STAT signaling resulting in potent inhibition of inflammatory cytokines with resultant immunosuppressive and anti-inflammatory activity.
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Purity
> 99% -
CAS Number
477600-75-2 -
Chemical structure
Properties
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Chemical name
(3R,4R)-3-[4-Methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile -
Molecular weight
312.37 -
Molecular formula
C16H20N6O -
PubChem identifier
9926791 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N -
Source
Synthetic
