Thiamet G, O-GlcNAcase inhibitor (ab146193)
Key features and details
- Potent, selective O-GlcNAcase inhibitor
- CAS Number: 1009816-48-1
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Thiamet G, O-GlcNAcase inhibitor -
Description
Potent, selective O-GlcNAcase inhibitor -
Biological description
Potent, selective O-GlcNAcase inhibitor (Ki = 21 nM). Blocks tau phosphorylation. Increases O-GlcNAc-modified protein levels (EC50 = 30 nM). Shows antitauopathic effects in vivo. Orally active. Blood-brain barrier permeable. -
CAS Number
1009816-48-1 -
Chemical structure
Properties
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Chemical name
2-(Ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol -
Molecular weight
248.30 -
Molecular formula
C9H16N2O4S -
PubChem identifier
53393934 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCNC1=NC2C(C(C(OC2S1)CO)O)O -
Source
Synthetic
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Research areas