Tertiapin Q, blocker of inward-rectifier r K+ channels (ab120432)
Key features and details
- Potent inward rectifier K+ channel blocker
- CAS Number: 252198-49-5
- Purity: > 95%
- Soluble in water
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Tertiapin Q, blocker of inward-rectifier r K+ channels -
Description
Potent inward rectifier K+ channel blocker -
Biological description
Potent blocker of inward rectifier K+ channels. Stable analog of the bee venom tertiapin. High affinity for ROMK1 and GIRK1/4 (Ki values are 1.3 and 13.3 nM, respectively). Displays >250-fold selectivity over many other Kir subtypes.
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Purity
> 95% -
General notes
Sold under license granted by the University of Pennsylvania. -
CAS Number
252198-49-5 -
Chemical structure
Properties
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Molecular weight
2452.01 -
Molecular formula
C106H175N35O24S4 -
Sequence
ALCNCNRIIIPHQCWKKCGKK (Modifications: C-terminal amide; Disulfide bonds: 3-14, 5-18) -
PubChem identifier
92131436 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC[C@H](C)[C@H]1C(=O)NC(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]3CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC3=O)CC4=CNC5=CC=CC=C54)CCCCN)CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N)C(=O)N[C@H](C(=O)N1)CC(=O)N)CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)CCC(=O)N)CC6=CNC=N6)[C@@H](C)CC)[C@@H](C)CC -
Source
Synthetic
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Research areas
Images
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Cellular activation - Tertiapin Q, blocker of inward-rectifier r K+ channels (ab120432) Image from Montalbano A, et al. Plos One, 10(10), e0140369. Fig 3,; doi: 10.1371/journal.pone.0140369Tertiapin Q, blocker of inward-rectifier r K+ channels