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Temsirolimus (CCI779), mTORC1 complex inhibitor  (ab141999)

Key features and details

  • Selective mTORC1 complex inhibitor (IC50 = 1.76 µM)
  • CAS Number: 162635-04-3
  • Purity: > 98%
  • Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Temsirolimus (CCI779), mTORC1 complex inhibitor 

  • Description

    Selective mTORC1 complex inhibitor (IC50 = 1.76 µM)

  • Alternative names

    • CCI-779
    • Torisel

  • Biological description

    Selective mTORC1 complex inhibitor (IC50 = 1.76 µM). Water-soluble rapamycin (ab120224) pro-drug. Rapidly converts to rapamycin in vivo. Inhibits proliferation and angiogenesis and induces apoptosis and autophagy in vivo.

  • Purity

    > 98%

  • CAS Number

    162635-04-3

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1R,2R,4S)-4-{(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.04 ,9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate

  • Molecular weight

    1030.29

  • Molecular formula

    C56H87NO16

  • PubChem identifier

    6918289

  • Storage instructions

    Store at -20°C. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC

  • Source

    Synthetic

  • Research areas

Images

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