Sulfosuccinimidyl oleate sodium, Fatty acid transport inhibitor (ab145039)
Key features and details
- Fatty acid transport inhibitor.
- CAS Number: 135661-44-8
- DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Sulfosuccinimidyl oleate sodium, Fatty acid transport inhibitor -
Description
Fatty acid transport inhibitor. -
Alternative names
- (Z)-2,5-Dioxo-1-[(1-oxo-9-octadecenyl)oxy]-3-pyrrolidinesulfonic Acid Sodium
- 2,5-Dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]-3-pyrrolidinesulfonic acid sodium salt
- Oleic acid N-Hydroxysulfosuccinamide ester sodium salt
- sulfo-N-succinimidyloleate sodium
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Biological description
Irreversible inhibitor of the fatty acid translocase CD36, blocking uptake of oleate, linoleate, or stearate by about 65% when added at 200 µM to adipocytes. It reduces the uptake of palmitate by mouse insulinoma MIN6 cells, preventing palmitate-induced changes in insulin secretion. Impairs saturated fatty acid-induced lipid accumulation and inflammation in RAW 264.7 macrophages.
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CAS Number
135661-44-8 -
Chemical structure
Properties
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Chemical name
2,5-Dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]-3-pyrrolidinesulfonic acid sodium salt -
Molecular weight
481.58 -
Molecular formula
C22H36NNaO7S -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
