SU 6668, PDGFR inhibitor (ab142156)
Key features and details
- Potent PDGFR inhibitor
- CAS Number: 252916-29-3
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SU 6668, PDGFR inhibitor -
Description
Potent PDGFR inhibitor -
Biological description
Potent PDGFRβ inhibitor (IC50 = 60 nM). Also inhibits VEGFR2 and FGFR1 (IC50 values are 2 and 3 μM respectively). Antiproliferative effects in vitro. Anticancer and proapoptotic activity in vivo. Orally active. -
Purity
> 98% -
CAS Number
252916-29-3 -
Chemical structure
Properties
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Chemical name
3-[2,4-Dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid -
Molecular weight
310.35 -
Molecular formula
C18H18N2O3 -
PubChem identifier
5995546 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O -
Source
Synthetic
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Research areas
- Biochemicals
- Pharmacology
- Receptors & Transporters
- Enzyme-Linked Receptors
- Receptor tyrosine kinases
- FGFR
- Biochemicals
- Pharmacology
- Receptors & Transporters
- Enzyme-Linked Receptors
- Receptor tyrosine kinases
- PDGFR
