SEN 12333, alpha7 nicotinic acetylcholine receptor (nAChR) agonist (ab142237)
Key features and details
- Potent, selective α7 nicotinic acetylcholine receptor (nAChR) agonist
- CAS Number: 874450-44-9
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SEN 12333, alpha7 nicotinic acetylcholine receptor (nAChR) agonist -
Description
Potent, selective α7 nicotinic acetylcholine receptor (nAChR) agonist -
Biological description
Potent, selective α7 nicotinic acetylcholine receptor (nAChR) agonist. High affinity for rat α7 receptors (Ki = 260 nM). Full agonist in functional Ca2+ flux studies (EC50 = 1.6 μM). Active in vivo and in vitro. Excellent brain penetration. Orally bioavailable.
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Purity
> 98% -
CAS Number
874450-44-9 -
Chemical structure
Properties
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Chemical name
N-[4-(3-Pyridinyl)phenyl]-4-morpholinepentanamide -
Molecular weight
339.44 -
Molecular formula
C20H25N3O2 -
PubChem identifier
45484303 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(Nc1ccc(cc1)c2cccnc2)CCCCN3CCOCC3 -
Source
Synthetic
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Research areas
