GTS-21 dihydrochloride (DMBX-A), alpha7 Nicotinic acetylcholine receptor agonist (ab120560)
Key features and details
- α7 Nicotinic acetylcholine receptor agonist
- CAS Number: 156223-05-1
- Purity: > 98%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GTS-21 dihydrochloride (DMBX-A), alpha7 Nicotinic acetylcholine receptor agonist -
Description
α7 Nicotinic acetylcholine receptor agonist -
Alternative names
- DMBX-A
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Biological description
Partial agonist at α7nACh receptors. Binds selectively to α7 subunits, with no significant activity seen at α2, α3 and α4. (EC50 = 10 μM in vitro (striatal slices)). Shown to elicit nootropic, neuroprotective and anti-inflammatory effects.
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Purity
> 98% -
CAS Number
156223-05-1 -
Chemical structure
Properties
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Chemical name
3-[(3E)-3-[(2,4-Dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine dihydrochloride -
Molecular weight
381.30 -
Molecular formula
C19H20N2O2.2HCl -
PubChem identifier
5310985 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=CC(=C(C=C1)/C=C/2\CCCN=C2C3=CN=CC=C3)OC -
Source
Synthetic
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Research areas
