SB 399885 hydrochloride, 5-HT6 antagonist (ab120332)
Key features and details
- Potent, selective 5-HT6 antagonist
- CAS Number: 402713-80-8
- Purity: > 99%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SB 399885 hydrochloride, 5-HT6 antagonist -
Description
Potent, selective 5-HT6 antagonist -
Biological description
Potent, selective competitive 5-HT6 antagonist (pKi values are 8.81 and 9.02 for rat and human native receptors, respectively). Orally active, cognitive enhancer in vivo. Displays >200-fold selectivity over 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT4, 5-HT7, α1B, D2, D3, D4 receptors, ion channels and a range of enzymes.
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Purity
> 99% -
CAS Number
402713-80-8 -
Chemical structure
Properties
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Chemical name
N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide hydrochloride -
Molecular weight
482.81 -
Molecular formula
C18H21Cl2N3O4S.HCl -
PubChem identifier
10277652 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Clc3cc(NS(=O)(=O)c1cc(c(cc1)OC)N2CCNCC2)c(OC)c(Cl)c3 -
Source
Synthetic
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Research areas
