SB 328437, CCR3 antagonist (ab120648)
Key features and details
- Highly potent and selective CCR3 antagonist
- CAS Number: 247580-43-4
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SB 328437, CCR3 antagonist -
Description
Highly potent and selective CCR3 antagonist -
Biological description
Highly potent and selective CCR3 antagonist (IC50 = 4 nM). Shows >2500-fold selectivity over CCR7, CXCR1, CXCR2, C4aR and LTD4 receptors. Inhibits Ca2+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 (IC50 values are 38, 35, and 20 nM, respectively). Also inhibits eosinophil chemotaxis.
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Purity
> 99% -
CAS Number
247580-43-4 -
Chemical structure
Properties
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Chemical name
N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalanine methyl ester -
Molecular weight
378.38 -
Molecular formula
C21H18N2O5 -
PubChem identifier
10474776 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC(=O)[C@H](CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32 -
Source
Synthetic
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Research areas
