SB 297006, CCR3 antagonist (ab120821)
Key features and details
- Potent, selective CCR3 antagonist
- CAS Number: 58816-69-6
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SB 297006, CCR3 antagonist -
Description
Potent, selective CCR3 antagonist -
Biological description
Highly potent, selective CCR3 antagonist (IC50 = 2.5 μM). Displays 250-fold selectivity for CCR3 vs. CXCR1, CXCR2, CCR1 and CCR7 receptors. Potent inhibitor of Ca2+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 in human eosinophils (IC50 values are 210, 90 and 80 nM, respectively).
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Purity
> 99% -
CAS Number
58816-69-6 -
Chemical structure
Properties
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Chemical name
N-Benzoyl-4-nitro-L-phenylalanine ethyl ester -
Molecular weight
342.35 -
Molecular formula
C18H18N2O5 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas