Sanguinarine chloride, PP2C inhibitor (ab141022)
Key features and details
- Selective PP2C inhibitor
- CAS Number: 5578-73-4
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Sanguinarine chloride, PP2C inhibitor -
Description
Selective PP2C inhibitor -
Biological description
Selective PP2C inhibitor. Inhibits MKP-1 (IC50 = 10 μM). Induces cell cycle arrest in the G1 phase. Induces ROS-mediated oxidative stress in growing cells. Shows antiproliferative and cytotoxic effects (IC50 = 7.6 μM for S-G gingival epithelial cells). Shows antitumor effects in vivo. Orally active. -
Purity
> 98% -
CAS Number
5578-73-4 -
Chemical structure
Properties
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Chemical name
13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride -
Molecular weight
367.79 -
Molecular formula
C20H14ClNO4 -
PubChem identifier
68635 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[N+]1=C2C(=C3C=CC4=C(C3=C1)OCO4)C=CC5=CC6=C(C=C52)OCO6.[Cl-] -
Source
Synthetic
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Research areas
