S3I-201 (DMSO solution), STAT3 inhibitor (ab146606)
Key features and details
- Selective STAT3 inhibitor
- CAS Number: 501919-59-1
- Purity: > 97%
- Supplied in DMSO (10 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
S3I-201 (DMSO solution), STAT3 inhibitor -
Description
Selective STAT3 inhibitor -
Biological description
Selective STAT3 inhibitor (IC50 values are 86, 160, 166 and >300 μM for STAT3.STAT3, STAT1.STAT3 STAT1.STAT1 and STAT5.STAT5 DNA binding activity respectively). Suppresses fibronectin, α-SMA, and collagen I expression. Shows apoptotic antiproliferative effects. Shows anti-inflammatory and analgesic effects in vivo. Centrally active.
Also available as a solid (ab141434). -
Purity
> 97% -
CAS Number
501919-59-1 -
Chemical structure
Properties
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Chemical name
2-Hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid -
Molecular weight
365.36 -
Molecular formula
C16H15NO7S -
PubChem identifier
252682 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Supplied in DMSO (10 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O -
Source
Synthetic
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Research areas