(S)-MCPG, Group I / II mGlu antagonist (ab120059)
Key features and details
- Group I / II mGlu antagonist
- CAS Number: 150145-89-4
- Purity: > 98%
- Soluble in 1.1eq. NaOH to 100mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
(S)-MCPG, Group I / II mGlu antagonist -
Description
Group I / II mGlu antagonist -
Purity
> 98% -
CAS Number
150145-89-4 -
Chemical structure
Properties
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Chemical name
(S)-a-Methyl-4-carboxyphenylglycine -
Molecular weight
209.20 -
Molecular formula
C10H11NO4 -
PubChem identifier
446355 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 1.1eq. NaOH to 100mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
N[C@](C)(C(=O)O)c1ccc(cc1)C(=O)O -
Source
Synthetic
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Research areas
Images
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Functional Studies - (S)-MCPG, Group I / II mGlu antagonist (ab120059)ab17722 staining FMRP in SK-N-SH cells treated with (S)-MCPG (ab120059), by ICC/IF. Decrease of FMRP expression correlates with increased concentration of (S)-MCPG, as described in literature.
The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab120059 ((S)-MCPG) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
