RS-1 (RAD51 Activator), RAD51 stimulator (ab222372)
Key features and details
- High affinity RAD51 stimulator
- CAS Number: 312756-74-4
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
RS-1 (RAD51 Activator), RAD51 stimulator -
Description
High affinity RAD51 stimulator -
Alternative names
- RAD51 Activator
- RAD51-stimulatory compound 1
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Biological description
High affinity human homologous recombination (HR) protein RAD51 stimulator. Low micromolar concentrations enhance DNA binding (Kd = 48-107 nM, dependent on cofactors present), and result in longer protein–DNA complex lengths. Enhances recombinogenic activity by stabilizing the active form of hRAD51 filaments without inhibiting hRAD51 ATPase activity. Enhances both TALEN and Cas9-mediated knock-in efficiency in rabbit embryos both in vitro and in vivo.
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Purity
> 98% -
CAS Number
312756-74-4 -
Chemical structure
Properties
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Chemical name
4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide -
Molecular weight
524.23 -
Molecular formula
C20H16Br2N2O3S -
PubChem identifier
1039737 -
Storage instructions
Shipped at 4°C. Store at -20°C long term. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C(C=C1)CNS(=O)(=O)C2=C(C=CC(=C2)C(=O)NC3=CC=C(C=C3)Br)Br -
Source
Synthetic
