Ro 67-4853, Positive allosteric modulator of mGlu1 (ab120979)
Key features and details
- PAM for mGlu1
- CAS Number: 302841-89-0
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ro 67-4853, Positive allosteric modulator of mGlu1 -
Description
PAM for mGlu1 -
Biological description
Potent, selective positive allosteric modulator for mGlu1 (pEC50 = 7.16 for rat mGlu1a receptors). Increases basal mGluR1-induced cAMP accumulation and potentiates glutamate-induced cAMP accumulation. Selectively enhanced responses to DHPG in vivo (EC50= 95 nM in CA3 neurons).
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Purity
> 99% -
CAS Number
302841-89-0 -
Chemical structure
Properties
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Chemical name
N-(9H-Xanthen-9-ylcarbonyl)carbamic acid butyl ester -
Molecular weight
325.36 -
Molecular formula
C19H19NO4 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
