Riluzole (PK 26124), GABA uptake inhibitor (ab120272)
Key features and details
- Neuroprotective agent. Modulates glutamate transmission.
- CAS Number: 850608-87-6
- Purity: > 99%
- Soluble in DMSO to 100 mM and in water to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Riluzole (PK 26124), GABA uptake inhibitor -
Description
Neuroprotective agent. Modulates glutamate transmission. -
Alternative names
- PK 26124
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Biological description
Neuroprotective agent with anticonvulsant, sedative, anxiolytic, anti-ischemic and anesthetic properties. Inhibits glutamate release, enhances glutamate uptake, blocks voltage-dependent Na+ channels, antagonises NMDA receptors and inhibits GABA uptake. Reported to offer neuroprotection and some therapeutic potential for amyotrophic lateral sclerosis and Huntingdon's disease.
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Purity
> 99% -
CAS Number
850608-87-6 -
Chemical structure
Properties
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Chemical name
2-Amino-6-trifluoromethoxybenzothiazole hydrochloride -
Molecular weight
270.66 -
Molecular formula
C8H5F3N2OS.HCl -
PubChem identifier
6419992 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in water to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.FC(F)(F)Oc1ccc2nc(N)sc2c1 -
Source
Synthetic
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Research areas
