Rhodadyntrade C10, cell-permeable dynamin I inhibitor (ab120795)
Key features and details
- Highly potent cell-permeable dynamin I inhibitor
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Rhodadyntrade C10, cell-permeable dynamin I inhibitor -
Description
Highly potent cell-permeable dynamin I inhibitor -
Biological description
Highly potent cell-permeable dynamin I GTPase activity inhibitor (IC50 values are 7.1 and 30.3 μM at dynamin I and dynamin II, respectively). Blocks clathrin-mediated endocytosis of transferrin when applied for 30 minutes to U2OS cells in culture (IC50 = 7.0 μM).
Rhodadyn™ B10 negative control also available (ab120796).
Robertson J et al. The rhodadyn™ a new class of small molecule inhibitors of dynamin GTPase. ACS Med. Chem (2012). -
Purity
> 98% -
General notes
Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovations Ltd. Rhodadyn™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd. -
Chemical structure
Properties
-
Chemical name
(5Z)-5-[4-[3-(Dimethylamino)propoxy]benzylidene]-3-ethyl-2-thioxo-1,3-thiazolidin-4-one -
Molecular weight
350.49 -
Molecular formula
C17H22N2O2S2 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Unstable; make up solutions fresh and use immediately.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
Source
Synthetic
-
Research areas
