Recombinant rat Macrophage Inflammatory Protein 1 alpha / CCL3 (Active) (ab256244)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Endotoxin level:
- Active: Yes
- Suitable for: SDS-PAGE, Functional Studies
Preparation and Storage
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Alternative names
- C C motif chemokine 3
- CCL 3
- CCL3
see all -
Function
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). -
Sequence similarities
Belongs to the intercrine beta (chemokine CC) family. -
Post-translational
modificationsN-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells. -
Cellular localization
Secreted. - Information by UniProt
Images
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SDS-PAGE - Recombinant rat Macrophage Inflammatory Protein 1 alpha / CCL3 (Active) (ab256244)
SDS-PAGE analysis of ab256244 (1μg) under reducing (Lane 1) and non-reducing (Lane 2) conditions.
ab256244 is a homodimer and therefore is predicted to have a MW of 7.9kD when run under reducing and non-reducing conditions.
4-20% Tris-Glycine gel. Coomassie Blue staining.
