Recombinant rat IL-1 alpha protein (ab200276)
Key features and details
- Expression system: Escherichia coli
- Purity: > 97% SDS-PAGE
- Active: Yes
- Suitable for: Functional Studies, HPLC, SDS-PAGE
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Product name
Recombinant rat IL-1 alpha protein
See all IL-1 alpha proteins and peptides -
Biological activity
The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.005 ng/mL, corresponding to a specific activity of > 2.0 × 108 IU/mg.
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Purity
> 97 % SDS-PAGE. -
Expression system
Escherichia coli -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Rat -
Sequence
SAPHSFQNNLRYKLIRIVKQEFIMNDSLNQNIYVDMDRIHLKAASLNDLQ LEVKFDMYAYSSGGDDSKYPVTLKVSNTQLFVSAQGEDKPVLLKEIPETP KLITGSETDLIFFWEKINSKNYFTSAAFPELLIATKEQSQVHLARGLPSM IDFQIS -
Predicted molecular weight
18 kDa -
Amino acids
115 to 270
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Preparation and Storage
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Alternative names
- BAF
- FAF
- Hematopoietin 1
see all -
Function
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. -
Sequence similarities
Belongs to the IL-1 family. -
Domain
The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. -
Cellular localization
Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. - Information by UniProt
