Antibodies, Proteins, Kits and Reagents for Life Science

Key features and details

Expression system: CHO cells
Purity: >= 98% SDS-PAGE
Endotoxin level:
Suitable for: SDS-PAGE

Product name

Recombinant Mouse ICOS Ligand/ICOSL protein (Fc Chimera)
See all ICOS Ligand/ICOSL proteins and peptides
Purity

>= 98 % SDS-PAGE.
Endotoxin level
Expression system

CHO cells
Accession

Q9JHJ8
Protein length

Protein fragment
Animal free

No
Nature

Recombinant
- Species
  
  Mouse
- Sequence
  
  TEVGAMVGSNVVLSCIDPHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSP GINVDSSYKNRGHLSLDSMKQGNFSLYLKNVTPQDTQEFTCRVFMNTATE LVKILEEVVRLRVAANFSTPVISTSDSSNPGQE RTYTCMSKNGYPEPN LYWINTTDNSLIDTALQNNTVYLNKLGLYDVISTLRLPWTSRGDVLCCVE NVALHQNITSISQAESFTGNNTKNPQETHNNEL
- Amino acids
  
  48 to 279
- Additional sequence information
  
  Extracellular domain fused to the N terminus of the Fc region of mouse IgG2a.

Our Abpromise guarantee covers the use of ab215004 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications

SDS-PAGE
Form

Lyophilized
Additional notes

This product was previously labelled as ICOS Ligand
Concentration information loading...

Stability and Storage

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

Constituent: 100% PBS

Lyophilized from 0.2 µm filtered solution.
Reconstitution

Reconstitute at 100 µg/mL in sterile PBS. Working aliquots are stable for up to 3 months when stored at -20°C.

Alternative names
- B7 H2
- B7 homolog 2
- B7 homologue 2
- B7 like protein Gl50
- B7 related protein 1
- B7-H2
- B7-like protein Gl50
- B7-related protein 1
- B7H2
- B7RP 1
- B7RP-1
- B7RP1
- CD 275
- CD275
- CD275 antigen
- GL 50
- GL50
- ICOS L
- ICOS LG
- ICOS ligand
- ICOSL
- ICOSL_HUMAN
- Icoslg
- Inducible T cell co stimulator ligand
- KIAA0653
- LICOS
- Transmembrane protein B7 H2 ICOS ligand
see all
Function

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
Tissue specificity

Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.
Sequence similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Cellular localization

Membrane.
Target information above from: UniProt accession O75144 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols