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Recombinant Mouse ICOS Ligand/ICOSL protein (Fc Chimera) (ab215004)

Key features and details

  • Expression system: CHO cells
  • Purity: >= 98% SDS-PAGE
  • Endotoxin level:
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant Mouse ICOS Ligand/ICOSL protein (Fc Chimera)
    See all ICOS Ligand/ICOSL proteins and peptides

  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    CHO cells

  • Accession

    Q9JHJ8

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Mouse

    • Sequence

      TEVGAMVGSNVVLSCIDPHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSP GINVDSSYKNRGHLSLDSMKQGNFSLYLKNVTPQDTQEFTCRVFMNTATE LVKILEEVVRLRVAANFSTPVISTSDSSNPGQE RTYTCMSKNGYPEPN LYWINTTDNSLIDTALQNNTVYLNKLGLYDVISTLRLPWTSRGDVLCCVE NVALHQNITSISQAESFTGNNTKNPQETHNNEL

    • Amino acids

      48 to 279

    • Additional sequence information

      Extracellular domain fused to the N terminus of the Fc region of mouse IgG2a.

    • Specifications

    Our Abpromise guarantee covers the use of ab215004 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Lyophilized

    • Additional notes

       This product was previously labelled as ICOS Ligand

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

      Constituent: 100% PBS

      Lyophilized from 0.2 µm filtered solution.

    • Reconstitution
      Reconstitute at 100 µg/mL in sterile PBS. Working aliquots are stable for up to 3 months when stored at -20°C.

    General Info

    • Alternative names

      • B7 H2
      • B7 homolog 2
      • B7 homologue 2
      • B7 like protein Gl50
      • B7 related protein 1
      • B7-H2
      • B7-like protein Gl50
      • B7-related protein 1
      • B7H2
      • B7RP 1
      • B7RP-1
      • B7RP1
      • CD 275
      • CD275
      • CD275 antigen
      • GL 50
      • GL50
      • ICOS L
      • ICOS LG
      • ICOS ligand
      • ICOSL
      • ICOSL_HUMAN
      • Icoslg
      • Inducible T cell co stimulator ligand
      • KIAA0653
      • LICOS
      • Transmembrane protein B7 H2 ICOS ligand
      see all

    • Function

      Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

    • Tissue specificity

      Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.

    • Sequence similarities

      Belongs to the immunoglobulin superfamily. BTN/MOG family.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    • Cellular localization

      Membrane.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab215004? Please let us know so that we can cite the reference in this datasheet.

ab215004 has not yet been referenced specifically in any publications.

Preparation and Storage

  • B7 H2
  • B7 homolog 2
  • B7 homologue 2

Images

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