Recombinant mouse Glypican 3 protein (Fc Chimera Active) (ab220573)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 90% SDS-PAGE
- Endotoxin level:
- Active: Yes
- Tags: Fc tag C-Terminus
- Suitable for: Functional Studies, SDS-PAGE, ELISA
Preparation and Storage
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Alternative names
- DGSX
- Glypican proteoglycan 3
- Glypican-3 [Precursor]
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Function
Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. -
Tissue specificity
Highly expressed in lung, liver and kidney. -
Involvement in disease
Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome type 1 (SGBS1) [MIM:312870]; also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies. -
Sequence similarities
Belongs to the glypican family. -
Cellular localization
Cell membrane and Secreted > extracellular space. - Information by UniProt
Images
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ELISA - Recombinant mouse Glypican 3 protein (Fc Chimera Active) (ab220573)
Recombinant human FGF2 protein (ab155734) at 2 μg/mL (100 μL/well) can bind ab220573 with a linear range of 1-10 ng/mL.
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SDS-PAGE - Recombinant mouse Glypican 3 protein (Fc Chimera Active) (ab220573)ab220573 on SDS-PAGE under reducing conditions stained overnight with Coomassie Blue. As a result of glycosylation, the reduced protein migrates as 100 kDa, 60 kDa and 40 kDa.
