• Product name

  Recombinant Mouse BCMA protein (Tagged)
  See all BCMA proteins and peptides

• Purity

  > 85 % SDS-PAGE.
  
  

• Expression system

  Mammalian

• Protein length

  Protein fragment

• Animal free

  No

• Nature

  Recombinant

• • Species

    Mouse

  • Predicted molecular weight

    20 kDa

  • Tags

    Fc tag C-Terminus

  • Additional sequence information

    Extracellular domain

• Alternative names

  • B cell maturation antigen
  • B cell maturation factor
  • B cell maturation protein

  • B-cell maturation protein
  • BCM
  • BCMA
  • CD269
  • CD269 antigen
  • TNFRSF17
  • TNR17_HUMAN
  • Tumor necrosis factor receptor superfamily member 17

  see all

• Function

  Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

• Tissue specificity

  Expressed in mature B-cells, but not in T-cells or monocytes.

• Involvement in disease

  Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

• Sequence similarities

  Contains 1 TNFR-Cys repeat.

• Cellular localization

  Cell membrane. Endomembrane system. Perinuclear Golgi-like structures.

• Target information above from: UniProt accession Q02223 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt