Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Human WISP1 protein (His tag) (ab276270)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: > 90% SDS-PAGE
  • Endotoxin level:
  • Tags: His tag C-Terminus
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant Human WISP1 protein (His tag)
    See all WISP1 proteins and peptides

  • Purity

    > 90 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    HEK 293 cells

  • Accession

    O95388-1

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MRWFLPWTLA AVTAAAASTV LATALSPAPT TMDFTPAPLE DTSSRPQFCK WPCECPPSPP RCPLGVSLIT DGCECCKMCA QQLGDNCTEA AICDPHRGLY CDYSGDRPRY AIGVCAQVVG VGCVLDGVRY NNGQSFQPNC KYNCTCIDGA VGCTPLCLRV RPPRLWCPHP RRVSIPGHCC EQWVCEDDAK RPRKTAPRDT GAFDAVGEVE AWHRNCIAYT SPWSPCSTSC GLGVSTRISN VNAQCWPEQE SRLCNLRPCD VDIHTLIKAG KKCLAVYQPE ASMNFTLAGC ISTRSYQPKY CGVCMDNRCC IPYKSKTIDV SFQCPDGLGF SRQVLWINAC FCNLSCRNPN DIFADLESYP DFSEIAN

    • Predicted molecular weight

      39 kDa including tags

    • Molecular weight information

      The secreted recombinant human WISP1 consisting of 356 amino acids has a calculated molecular mass of 39 kDa. As a result of glycosylation, it migrates as an approximately 55 kDa protein in SDS-PAGE under reducing conditions.

    • Amino acids

      1 to 367

    • Tags

      His tag C-Terminus

    • Additional sequence information

      Predicted N-terminus: Thr 23.

    • Specifications

    Our Abpromise guarantee covers the use of ab276270 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at Room Temperature. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 7.40
      Constituent: 100% PBS

    • Reconstitution
      This information is lot specific. Please contact our technical Support team for details.

    General Info

    • Alternative names

      • CCN 4
      • CCN family member 4
      • CCN4
      • WISP 1
      • WISP 1c
      • WISP 1i
      • WISP 1tc
      • WISP1c
      • WISP1i
      • WISP1tc
      • Wnt 1 induced secreted protein
      • WNT 1 induced secreted protein 1
      • WNT 1 inducible signaling pathway protein 1
      • Wnt 1 signaling pathway protein 1
      • Wnt-1 inducible signaling pathway protein 1
      • Wnt1 induced secreted protein
      • WNT1 induced secreted protein 1
      • WNT1 inducible signaling pathway protein 1
      • Wnt1 signaling pathway protein 1
      • WNT1-inducible-signaling pathway protein 1
      see all

    • Relevance

      WISP1 is a downstream regulator in the Wnt/Frizzled-signaling pathway and is associated with cell survival. WISP1 attentuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase and up-regulates the anti-apoptotic Bcl-X(L) protein. WISP1 is expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Overexpression is associated with several cancers including breast cancer and colon tumors.

    • Cellular localization

      Secreted

Images

  • SDS-PAGE - Recombinant Human WISP1 protein (ab276270)
    SDS-PAGE - Recombinant Human WISP1 protein (ab276270)
    SDS-PAGE analysis of ab276270

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab276270? Please let us know so that we can cite the reference in this datasheet.

ab276270 has not yet been referenced specifically in any publications.

Preparation and Storage

  • CCN 4
  • CCN family member 4
  • CCN4

Images

  • SDS-PAGE - Recombinant Human WISP1 protein (ab276270)
    SDS-PAGE - Recombinant Human WISP1 protein (ab276270)
    SDS-PAGE analysis of ab276270

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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