Antibodies, Proteins, Kits and Reagents for Life Science

Recombinant human VEGF Receptor 1 protein (ab54344)

Key features and details

Expression system: Insect cells
Purity: > 90% SDS-PAGE
Active: Yes
Suitable for: SDS-PAGE, Functional Studies

Product name

Recombinant human VEGF Receptor 1 protein
See all VEGF Receptor 1 proteins and peptides
Purity

> 90 % SDS-PAGE.
Expression system

Insect cells
Protein length

Protein fragment
Animal free

No
Nature

Recombinant
- Species
  
  Human

Alternative names
- EC 2.7.10.1
- FLT
- FLT 1
- Flt-1
- FLT1
- Fms like tyrosine kinase 1
- Fms related tyrosine kinase 1
- Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
- Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor
- Fms-like tyrosine kinase 1
- FRT
- Soluble VEGF receptor 1 14
- Soluble VEGFR1 variant 2
- Soluble VEGFR1 variant 21
- Tyrosine protein kinase FRT
- Tyrosine protein kinase receptor FLT
- Tyrosine-protein kinase FRT
- Tyrosine-protein kinase receptor FLT
- Vascular endothelial growth factor receptor 1
- Vascular endothelial growth factor vascular permeability factor receptor
- Vascular permeability factor receptor
- Vascular permeability factor receptor 1
- VEGFR 1
- VEGFR-1
- VEGFR1
- VGFR1_HUMAN
see all
Function

Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.
Tissue specificity

Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform sFlt1 is strongly expressed in placenta.
Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
Cellular localization

Secreted and Cell membrane.
Target information above from: UniProt accession P17948 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

Functional Studies - Recombinant human VEGF Receptor 1 protein (ab54344)

Inhibition of the VEGF165-induced proliferation of HUVE cells by recombinant human endogenous sFlt-1 and sFlt-1 constructs. HUVECs were stimulated with 10 ng/ml VEGF165, the soluble receptors were added with a 100X excess.
SDS-PAGE - Recombinant human VEGF Receptor 1 protein (ab54344)

SDS-PAGE analysis of recombinant human soluble VEGFR-1D1-4 produced in insect cells. Sample was loaded in 10% SDS-polyacrylamide gel under reducing condition and stained with Silver stain.

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