Recombinant Human Ubiquitin +1 protein (ab82625)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE
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Product name
Recombinant Human Ubiquitin +1 protein -
Purity
> 95 % SDS-PAGE. -
Expression system
Escherichia coli -
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human
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Preparation and Storage
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Alternative names
- UBB
- Ubiquitin
- Ubiquitin B
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Relevance
Ubiquitin +1 (Ub+1) is a novel mutant form of ubiquitin that can be produced through a process known as molecular frameshift. Ub+1 can be polyubiquitinated to produce aberrant polyubiquitin chains that inhibit the 26S proteasome. Especially Ub+1 is accumulated in aggregates containing amyloid beta and phosphorylated tau. Elevated expression of Ub+1 mRNA and protein has been observed in the brains of patients with Alzheimer's disease. Also Ub+1 acts as an aggravating factor in polyglutamine induced neurodegeneration. -
Cellular localization
Cytoplasmic and Nuclear
Images
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SDS-PAGE - Recombinant Human Ubiquitin +1 protein (ab82625)ab82625 at 1µg on SDS-PAGE.