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Recombinant Human TrkB protein (ab151671)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Tags: His tag C-Terminus
  • Suitable for: SDS-PAGE, HPLC

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    pH: 7.20
    Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

  • Reconstitution
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at

    General Info

    • Alternative names

      • AI848316
      • BDNF tropomyosine receptor kinase B
      • BDNF/NT 3 growth factors receptor
      • BDNF/NT-3 growth factors receptor
      • Brain derived neurotrophic factor receptor
      • C030027L06Rik
      • EC 2.7.10.1
      • GP145 TrkB
      • GP145-TrkB
      • GP145-TrkB/GP95-TrkB
      • GP95 TrkB
      • Neurotrophic receptor tyrosine kinase 2
      • Neurotrophic tyrosine kinase receptor type 2
      • Neurotrophin receptor tyrosine kinase type 2
      • NTRK 2
      • Ntrk2
      • NTRK2_HUMAN
      • Obesity, hyperphagia, and developmental delay, included
      • RATTRKB1
      • Tkrb
      • Trk B
      • Trk-B
      • TRKB
      • TrkB tyrosine kinase
      • TRKB1
      • Tropomyosin related kinase B
      • tyrosine kinase receptor B
      • Tyrosine receptor kinase B
      see all

    • Function

      Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

    • Tissue specificity

      Isoform TrkB is widely expressed, mainly in the nervous tissue. In the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in brain.

    • Sequence similarities

      Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 2 LRR (leucine-rich) repeats.
      Contains 1 LRRCT domain.
      Contains 1 LRRNT domain.
      Contains 1 protein kinase domain.

    • Post-translational
      modifications

      Ligand-mediated auto-phosphorylation.

    • Cellular localization

      Membrane.
    • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

References (0)

Publishing research using ab151671? Please let us know so that we can cite the reference in this datasheet.

ab151671 has not yet been referenced specifically in any publications.

Images

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