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Recombinant Human TIMP1 protein (ab151942)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Tags: His tag C-Terminus
  • Suitable for: SDS-PAGE, HPLC

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C.

    pH: 7.4
    Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

  • Reconstitution
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at

    General Info

    • Alternative names

      • Clgi
      • Collagenase inhibitor
      • Collagenase inhibitor, Human
      • EPA
      • EPO
      • Erythroid Potentiating Activity
      • Erythroid-potentiating activity
      • Fibroblast collagenase inhibitor
      • FLJ90373
      • HCI
      • Human Collagenase Inhibitor
      • Metalloproteinase inhibitor 1
      • Metalloproteinase inhibitor 1 precursor
      • OTTHUMP00000023214
      • TIMP
      • TIMP 1
      • TIMP metallopeptidase inhibitor 1
      • TIMP-1
      • Timp1
      • TIMP1 protein
      • TIMP1_HUMAN
      • Tissue Inhibitor of Metalloproteinase 1
      • Tissue inhibitor of metalloproteinases
      • Tissue inhibitor of metalloproteinases 1
      • Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor
      see all

    • Function

      Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.

    • Sequence similarities

      Belongs to the protease inhibitor I35 (TIMP) family.
      Contains 1 NTR domain.

    • Post-translational
      modifications

      The activity of TIMP1 is dependent on the presence of disulfide bonds.

    • Cellular localization

      Secreted.
    • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

References (0)

Publishing research using ab151942? Please let us know so that we can cite the reference in this datasheet.

ab151942 has not yet been referenced specifically in any publications.

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